The Novina lab focuses on the fundamental biology of non-coding RNAs and their development as biomedical tools. We use these tools to study the biology of RNA-regulated processes and to accelerate the translation of biological discoveries into novel therapies. These areas have numerous biological, technical, and translational synergies. For instance, (1) we use our RNA discovery platform to identify non-coding RNAs and their interacting proteins relevant for cancers, bone marrow failure and immune cell function (2) identify RNAs and small molecules that inhibit these interactions and (3) use these inhibitors to model hematopoietic and cancer immunotherapies. (4) We also develop Cas9-based epigenetic editing tools to target coding and non-coding loci to model hematopoietic and cancer immunotherapies. Please click the icons below to learn more about each area of these programs.